I’ve recently had my antidepressant medication changed yet again, since it no longer appeared to be as effective. I was switched from Prozac to Effexor XR.
Given that I have an extensive history of struggling with depression, I’ve tried a wide variety of antidepressants over the years. Eventually, each of them have stopped being as effective over time.
Some antidepressants have had more extensive side effects, such as the tricyclic antidepressants that I starting taking while in high school. They caused me to rapidly gain a significant amount of weight, which is most unhelpful for an adolescent female who feels depressed.
More recently, I’ve been prescribed serotonin-specific re-uptake inhibitors (SSRI’s). Overall, I’ve found their side effects to be tolerable. Nevertheless, they have also diminished in efficacy over time.
Effective management of long-term depression requires patience and flexibility. It most frequently involves periodically needing to change antidepressant medications.